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| Nomenclature |
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Symbol:
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Tspan12tm1Wye
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Name:
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tetraspanin 12;
targeted mutation 1, Weilan Ye
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MGI ID: |
MGI:4414643 |
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Gene:
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Tspan12
Location:
Chr6:21771395-21852515 bp, - strand
Genetic Position: Chr6,
8.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:154863
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Parent Cell Line:
| Lex-2 (ES Cell) |
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Strain of Origin:
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129S5/SvEvBrd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The translation initiation site and a major portion of the first transmembrane spanning domain of exon 3 were replaced with a IRES, beta-geo, and puro cassette. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:154863)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tspan12 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:154863
Junge HJ et al.,
"TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4/beta-catenin signaling."
Cell 2009 Oct 16;139(2):299-311
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All: |
1 reference(s)
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Analysis Tools
