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| Nomenclature |
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Symbol:
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Wt1tm1.1Lahe
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Name:
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Wilms tumor 1 homolog;
targeted mutation 1.1, Laurence Heidet
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MGI ID: |
MGI:4413579 |
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Synonyms: |
Wt1mut |
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Gene:
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Wt1
Location:
Chr2:105126529-105173616 bp, + strand
Genetic Position: Chr2,
55.06 cM, cytoband E
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:154995
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Parent Cell Line:
| CK35 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Mutations were introduced at c.C1180T and c.C1179A. The latter is silent while the former produces an amino acid substitution of tryphtophan for arginine at position 394 (R394W). A floxed neo cassette inserted downstream of the modified exon 9 was removed by cre mediated recombination. (J:154995)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Wt1 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:154995
Ratelade J et al.,
"A murine model of Denys-Drash syndrome reveals novel transcriptional targets of WT1 in podocytes."
Hum Mol Genet 2010 Jan 1;19(1):1-15
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All: |
1 reference(s)
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Analysis Tools
