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| Nomenclature |
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Symbol:
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Tg(SNCA*A53T)1Nbm
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Name:
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transgene insertion 1, Robert L Nussbaum
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MGI ID: |
MGI:4412061 |
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Synonyms: |
PAC-Tg(SCNAA53T |
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Transgene:
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Tg(SNCA*A53T)1Nbm
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: To generate the PAC-Tg(SNCAA53T) transgene, the 146 kb RPCI-1 human male P1 artificial chromosome (PAC) clone 27M07, containing the entire human SNCA (synuclein, alpha (non A4 component of amyloid precursor)) gene and 34 kb of its upstream region, was modified to have the A53T human mutation associated with autosomal dominant Parkinson's disease. This transgene was microinjected into the pronuclei of fertilized FVB/N ova. One transgenic insertion is present in the genome. (J:154972, J:156741)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:156741
Kuo YM et al.,
"Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated {alpha}-synuclein gene mutations precede central nervous system changes."
Hum Mol Genet 2010 Jan 27;():
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All: |
2 reference(s)
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Analysis Tools
