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| Nomenclature |
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Symbol:
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Tg(HBB-AR-HBA2,-HBB*)58Rub
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Name:
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transgene insertion 58, Edward M Rubin
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MGI ID: |
MGI:4411997 |
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Synonyms: |
alphabetaS Antilles |
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Transgene:
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Tg(HBB-AR-HBA2,-HBB*)58Rub
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Swiss Webster
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The 800 bp DNA fragment containing the hypersensitive II region of the human HBB locus control region was used to drive erythroid-specific expression of human HBA2 and human HBB containing the Sickle Antilles mutations (G6V and V23I) in co-injected constructs. Two founders were generated (14 and 58). The line from founder 58 contains 4 copies of the HBA2 expressing construct and 10 copies of the HBB* expressing construct. (J:136653)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:136653
Rubin EM et al.,
"Hypoxia-induced in vivo sickling of transgenic mouse red cells."
J Clin Invest 1991 Feb;87(2):639-47
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All: |
4 reference(s)
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Analysis Tools
