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| Nomenclature |
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Symbol:
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Tg(tetO-ATXN3)2904Olri
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Name:
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transgene insertion 2904, Olaf Riess
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MGI ID: |
MGI:4410556 |
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Synonyms: |
MJD77 |
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Transgene:
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Tg(tetO-ATXN3)2904Olri
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The tetracycline response element was used to drive inducible expression of the human gene with 77 CAG repeats. Five lines were created (lines 2909, 2776, 2285, 2904, and 2723) with different transgene copy numbers and CAG repeats. Line 2904 contains three copies of the transgene with 60, 65, and 80 CAG repeats per copy. This line also exhibits the highest level of protein expression. (J:154079)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:154079
Boy J et al.,
"Reversibility of symptoms in a conditional mouse model of spinocerebellar ataxia type 3."
Hum Mol Genet 2009 Nov 15;18(22):4282-95
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All: |
1 reference(s)
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Analysis Tools
