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| Nomenclature |
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Symbol:
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Scn4atm1.1Ljh
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Name:
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sodium channel, voltage-gated, type IV, alpha;
targeted mutation 1.1, Lawrence J Hayward
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MGI ID: |
MGI:4366146 |
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Synonyms: |
SCN4aM1592V |
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Gene:
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Scn4a
Location:
Chr11:106318592-106353288 bp, - strand
Genetic Position: Chr11,
68.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:153497
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: The targeting vector inserts a missense substitution changing a methionine to a valine at amino acid position 1592 (M1592V) in exon 24 and a loxP flanked neo cassette in intron 23. The neo cassette is removed by transient infection with a Cre recombinase expressing plasmid leaving a single loxP site downstream of exon 23. (J:135831, J:153497)
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Inheritance: | |
Recessive |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:153497
Hayward L,
"Creation of the M1592V mutation in Scn4a"
MGI Direct Data Submission 2009;():
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All: |
2 reference(s)
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Analysis Tools
