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| Nomenclature |
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Symbol:
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Rnf128tm1.1Flv
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Name:
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ring finger protein 128;
targeted mutation 1.1, Richard Flavell
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MGI ID: |
MGI:4365554 |
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Synonyms: |
GRAIL- |
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Gene:
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Rnf128
Location:
ChrX:139563316-139673145 bp, + strand
Genetic Position: ChrX,
61.35 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:153216
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Parent Cell Line:
| TC1/TC-1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A loxP-flanked neomycin cassette was placed in intron 6 and a third loxP site was placed in intron 3. Cre mediated recombination removed exons 4 through 6. This deletion results in a out of frame mutation. The absence of protein expression was confirmed by western blot on spleen, thymus, kidney, liver, and brain extracts. (J:153216)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:153216
Kriegel MA et al.,
"E3 ubiquitin ligase GRAIL controls primary T cell activation and oral tolerance."
Proc Natl Acad Sci U S A 2009 Sep 29;106(39):16770-5
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All: |
1 reference(s)
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Analysis Tools
