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| Nomenclature |
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Symbol:
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Tg(Eno2-ATN1)3Tx
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Name:
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transgene insertion 3, Tian Xu
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MGI ID: |
MGI:4360669 |
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Synonyms: |
Atro-118Q3 |
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Transgene:
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Tg(Eno2-ATN1)3Tx
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6J x SJL/J
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene comprises a cDNA encoding full length human ATN1 containing a 118 residue polyglutamine tract, encoded by 118 CAG repeats, inserted into a transgenic vector containing the rat neuron-specific enolase promoter. This transgenic line carries one copy of the construct and, as shown by immunohistology and western blot analyses, expresses human ATN1 protein in the brain. (J:112706)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:112706
Ying M et al.,
"Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA."
J Biol Chem 2006 May 5;281(18):12580-6
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All: |
2 reference(s)
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Analysis Tools
