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| Nomenclature |
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Symbol:
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Dp(7Herc2-Mkrn3)1Taku
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Name:
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duplication, Chr 7, Toru Takumi 1
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MGI ID: |
MGI:4359729 |
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Synonyms: |
Dp |
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Gene:
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Dp(7Herc2-Mkrn3)1Taku
Location:
unknown
Genetic Position: Chr7,
Syntenic
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:151648
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Parent Cell Line:
| AB2.2 (ES Cell) |
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Strain of Origin:
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129S7/SvEvBrd-Hprtb-m2
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Mutation
description |
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Allele
Type: | |
Targeted (other) |
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Mutation: | |
Duplication |
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Mutation details: Sequential rounds of targeting inserted the selection cassettes and loxP sites proximal to the Herc2 and distal to Mkrn3. A double-targeted clone in which the targeting had occurred on the homologous chromosomes (trans)was transiently transfected with a Cre recombinase in ES cells to induce recombination between the loxP sites on opposite chromosomes, which generated clones with a balanced duplication and deletion of 6.3 Mb region between Herc2 and Mkrn3. Only duplicated allele can be recovered after meiosis and mating. (J:151648)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Dp(7Herc2-Mkrn3)1Taku Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:151648
Nakatani J et al.,
"Abnormal behavior in a chromosome-engineered mouse model for human 15q11-13 duplication seen in autism."
Cell 2009 Jun 26;137(7):1235-46
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All: |
3 reference(s)
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Analysis Tools
