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| Nomenclature |
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Symbol:
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Tg(Prnp-TARDBP*A315T)95Balo
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Name:
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transgene insertion 95, Robert Baloh
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MGI ID: |
MGI:4358722 |
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Synonyms: |
Prp-TDP43A315T, Prp-TDP43-A315T |
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Transgene:
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Tg(Prnp-TARDBP*A315T)95Balo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C57BL/6 x CBA
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The construct contains the full-length human TAR DNA binding protein (TARDBP or TDP-43) cDNA sequence that was modified to harbor an N-terminal Flag tag immediately after the start methionine and the A315T amino acid substitution associated with familial ALS inserted between exon 2 and exon 3 of mouse prion protein (PrP or Prnp) gene. The Prp-TDP43A315T transgene was microinjected into oocytes from hybrid C57BL/6J x CBA mice and a single Prp-TDP43A315T founder line was established (founder line 95). (J:153197)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:153197
Wegorzewska I et al.,
"TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration."
Proc Natl Acad Sci U S A 2009 Oct 15;():
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All: |
2 reference(s)
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Analysis Tools
