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| Nomenclature |
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Symbol:
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Terf1tm1.1Blas
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Name:
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telomeric repeat binding factor 1;
targeted mutation 1.1, Maria A Blasco
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MGI ID: |
MGI:4357772 |
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Synonyms: |
TRF1flox |
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Gene:
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Terf1
Location:
Chr1:15805658-15843428 bp, + strand
Genetic Position: Chr1,
4.88 cM, cytoband E3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:152077
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted in the 5'UTR and an frt flanked neo cassette with a 5' loxP site was inserted into intron 1. Germ line, flp mediated recombination removed the neo cassette leaving exon 1 floxed. (J:152077)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Terf1 Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:152077
Martinez P et al.,
"Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice."
Genes Dev 2009 Sep 1;23(17):2060-75
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All: |
3 reference(s)
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Analysis Tools
