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| Nomenclature |
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Symbol:
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Tg(tetO-Ifng)184Pop
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Name:
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transgene insertion 184, Brian Popko
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MGI ID: |
MGI:4355871 |
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Synonyms: |
line 184 TRE/IFNg, line 184 TRE/IFN-g, line 184 TRE/IFN-gamma, TRE/IFN-gamma 184, TRE/IFN-gamma line 184 |
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Transgene:
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Tg(tetO-Ifng)184Pop
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The TRE/IFN-gamma transgene was designed with the PhCMV*-1 tetracycline-responsive promoter upstream of a mouse IFN-g cDNA sequence. The PhCMV*-1 tetracycline-responsive promoter contains the human cytomegalovirus (hCMV) minimal promoter fused to the tet-operator (tetO; TRE). The IFN-g cDNA is flanked by 40 bp of 5' and 57 bp of 3' UTR sequences and includes the translation start and stop signals. The sequences that confer IFN-g mRNA instability have been eliminated from the IFN-g cDNA sequence in an effort to increase steady-state mRNA levels derived from the transgene. This 2.3 kb transgene was microinjected into fertilized B6D2F1 oocytes. Founder line 184 was established. (J:94092)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:94092
Lin W et al.,
"Interferon-gamma induced medulloblastoma in the developing cerebellum."
J Neurosci 2004 Nov 10;24(45):10074-83
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All: |
4 reference(s)
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Analysis Tools
