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| Nomenclature |
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Symbol:
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Ifnb1tm2.1Lien
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Name:
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interferon beta 1, fibroblast;
targeted mutation 2.1, Stefan Lienenklaus
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MGI ID: |
MGI:4355683 |
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Synonyms: |
IFN-Bflox beta-luc, IFN-Bfloxbeta-luc |
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Gene:
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Ifnb1
Location:
Chr4:88522025-88522774 bp, - strand
Genetic Position: Chr4,
41.91 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:151854
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Parent Cell Line:
| Bruce 4 (ES Cell) |
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Strain of Origin:
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B6.Cg-Thy1a
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted 42 bp upstream of the lone coding exon and a Frt-flanked neomycin cassette, another loxP site, and a myc-tagged luciferase coding sequence were inserted downstream of the exon in the BstAPI restriction site. After targeting in C57BL/6 ES cells, the neomycin cassette was removed by crossing founder mice with FLP-deleter mice. A poly-A sequence upstream of the luciferase cassette prevents transcription of the reporter until the endogenous exon is floxed.
(J:151854)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ifnb1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:151854
Lienenklaus S et al.,
"Novel reporter mouse reveals constitutive and inflammatory expression of IFN-beta in vivo."
J Immunol 2009 Sep 1;183(5):3229-36
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All: |
2 reference(s)
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Analysis Tools
