Tg(Ckm-Ppargc1b)T37Brsp
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Ckm-Ppargc1b)T37Brsp
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Name:
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transgene insertion T37, Bruce M Spiegelman
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MGI ID: |
MGI:4354127 |
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Synonyms: |
MCK-PGC-1b, PGC-1b |
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Transgene:
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Tg(Ckm-Ppargc1b)T37Brsp
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A transgenic construct containing the complete mouse peroxisome proliferative activated receptor, gamma, coactivator 1 beta gene cDNA, the 4.8kb mouse muscle creatine kinase promoter and the human growth hormone polyadenylation site was injected into fertilized FVB mouse eggs. Three lines were generated. Founder line T37 was subsequently established. Expression of Ppargc1b mRNA is increased 10-fold in the quadriceps, and transgene expression is higher in 'white', glycolytic muscle (EDL, quadriceps, gastrocnemius) than in 'red', oxidative muscle (soleus, heart). (J:118258)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:118258
Arany Z et al.,
"The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle."
Cell Metab 2007 Jan;5(1):35-46
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All: |
2 reference(s)
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Analysis Tools
