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| Nomenclature |
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Symbol:
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Sox17tm1(icre)Heli
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Name:
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SRY-box containing gene 17;
targeted mutation 1, Heiko Lickert
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MGI ID: |
MGI:3852645 |
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Synonyms: |
Sox17iCre, Sox17iCredeltaneo, Sox17tm1(icre)Lic |
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Gene:
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Sox17
Location:
Chr1:4490928-4496413 bp, - strand
Genetic Position: Chr1,
1.65 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:150862
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Parent Cell Line:
| TBV2 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A targeting vector containing a mini gene locus with a codon improved cre recombinase cDNA with a translational stop codo, splice donor site, artificial intron and an exon encoding the SV40 polyadenylation signal followed by an FRT-flanked PGK-neo cassette in the opposite orientation was introduced into exon 1 of Sox17 by homologous recombination in TBV2 ES cells. Germline chimeras were generated and the neo cassette was excised by crossing these with Flpe mice. (J:150862)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sox17 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:150862
Liao WP et al.,
"Generation of a mouse line expressing Sox17-driven Cre recombinase with specific activity in arteries."
Genesis 2009 Jul;47(7):476-83
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All: |
1 reference(s)
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Analysis Tools
