Transgene Type:		Transgenic (Cre/Flp)
Mutation:		Insertion
		Mutation details: An enhancer trap transgenic approach was used to generate these mice. The hsyn-bgi-cre:ERT2-bGHpA transgene was designed with the human synapsin minimal promoter (hsyn) minimal promoter driving a cre-ERT2 fusion gene (cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain).A beta globin intron separates the promoter from the cre gene and the bovine growth hormone polyadenylation signal follows the cre sequence. This transgene was injected into C57BL/6J embryos. Founder line 2007 was established on a C57BL/6J genetic background. (J:150856)

Activity in:	nervous system
Driver:	enhancer trap     Summary of all recombinase alleles driven by enhancer trap.

Original:	J:150856 Davis R, "Large-scale enhancer trap project to generate transgenic cre alleles by Ron Davis at Baylor University" MGI Direct Data Submission 2009;():
All:	2 reference(s)