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| Nomenclature |
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Symbol:
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Cngb1tm1Sjpi
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Name:
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cyclic nucleotide gated channel beta 1;
targeted mutation 1, Steven J Pittler
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MGI ID: |
MGI:3851598 |
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Synonyms: |
Cngb1-X1 KO |
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Gene:
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Cngb1
Location:
Chr8:95239043-95306585 bp, - strand
Genetic Position: Chr8,
47.12 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:150504
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129S/SvEv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A genomic fragment including exons 1 and 2 was replaced with a pgk-neo cassette via homologous recombination. Northern blot analysis confirmed the absence of RNA expression in homozygous mice. Western blot analysis confirmed the absence of protein expression in rod outer segments from homozygous mice. (J:150504)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cngb1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:150504
Zhang Y et al.,
"Knockout of GARPs and the beta-subunit of the rod cGMP-gated channel disrupts disk morphogenesis and rod outer segment structural integrity."
J Cell Sci 2009 Apr 15;122(Pt 8):1192-200
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All: |
2 reference(s)
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Analysis Tools
