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| Nomenclature |
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Symbol:
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Tg(Scn1a*)RH9Aesc
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Name:
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transgene insertion RH9, Andrew Escayg
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MGI ID: |
MGI:3851210 |
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Synonyms: |
Scn1aTg-RH9 |
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Transgene:
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Tg(Scn1a*)RH9Aesc
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A BAC (clone 259E13) of size 187 kb containing mouse genomic sequence extending from 115 kb upstream of the Scn1a translation start site to 3 kb downstream from the polyA termination signal was modified to add a FLAG tag, an E954Q substitution (confering TTX and STX resistance), and an R1648H substitution (homologous to a mutation seen in human patients with Generalized Epilepsy with Febrile Seizures Plus). Two lines were generated, RH5 and RH9. Line RH9 had the highest level of transgene expression. (J:150454)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:150454
Tang B et al.,
"A BAC transgenic mouse model reveals neuron subtype-specific effects of a Generalized Epilepsy with Febrile Seizures Plus (GEFS+) mutation."
Neurobiol Dis 2009 Jul;35(1):91-102
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All: |
1 reference(s)
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Analysis Tools
