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| Nomenclature |
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Symbol:
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Tg(Acta2-RAC1*G12V)33Pjgc
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Name:
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transgene insertion 33, Pascal J Goldschmidt-Clermont
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MGI ID: |
MGI:3850849 |
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Synonyms: |
RacCA |
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Transgene:
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Tg(Acta2-RAC1*G12V)33Pjgc
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The cDNA coding for human RAC1 was mutated with a glycine 12 to valine substitution. The cDNA of RacCA, including its polyadenylation tail, was cloned within the Smp-8 plasmid that contained a 3.6 kb segment of the 5 kb-region of SMA promoter. The SMA promoter was used to induce selective overexpression of RacCA in SMCs. The purified fragment was microinjectedinto fertilized mouse eggs from FVB/N females, (J:150479)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:150479
Hassanain HH et al.,
"Hypertension caused by transgenic overexpression of Rac1."
Antioxid Redox Signal 2007 Jan;9(1):91-100
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All: |
3 reference(s)
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Analysis Tools
