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| Nomenclature |
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Symbol:
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Sox21tm1.1Ysa
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Name:
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SRY-box containing gene 21;
targeted mutation 1.1, Yumiko Saga
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MGI ID: |
MGI:3849852 |
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Gene:
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Sox21
Location:
Chr14:118233232-118237030 bp, - strand
Genetic Position: Chr14,
61.92 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:150086
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Parent Cell Line:
| TT2 (ES Cell) |
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Strain of Origin:
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(C57BL/6NCrlj x CBA/JNCrlj)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The entire coding sequence was replaced with an in frame EGFP cDNA and a floxed pgk-neo cassette. Cre mediated recombination then removed the neo cassette. In situ hybridization analysis confirmed the absence of expression in the hair follicles from homozygous mice. (J:150086)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Sox21 Mutation:
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0 strains or lines available |
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| References |
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Original: |
J:150086
Kiso M et al.,
"The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice."
Proc Natl Acad Sci U S A 2009 Jun 9;106(23):9292-7
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All: |
2 reference(s)
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Analysis Tools
