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| Nomenclature |
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Symbol:
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Tg(Prnp-FTL*)4Ruvi
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Name:
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transgene insertion 4, Ruben Vidal
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MGI ID: |
MGI:3848965 |
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Synonyms: |
FTL-Tg4, MoPrP-FTL498-499InsTC |
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Transgene:
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Tg(Prnp-FTL*)4Ruvi
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C3HeB/FeJ
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter was used to drive brain and heart specific expression of the human cDNA with TC insertions at the cDNA positions 498 and 499, respectively. This insertion leads to a frame-shift that alters the last 9 amino acids of the C-terminus and adds 16 additional amino acids. Four lines were created (lines 1, 2, 3, and 4) with 40 to 50, 5 to 10, 1 to 5, and 1 to 5 copies of the transgene, respectively. Line 4 was used for subsequent studies. (J:131053)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:131053
Vidal R et al.,
"Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice."
J Neurosci 2008 Jan 2;28(1):60-7
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All: |
2 reference(s)
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Analysis Tools
