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| Nomenclature |
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Symbol:
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Apctm1Ecrm
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Name:
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adenomatosis polyposis coli;
targeted mutation 1, Els C Robanus-Maandag
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MGI ID: |
MGI:3848479 |
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Synonyms: |
Apc15lox, Apcex15lox |
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Gene:
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Apc
Location:
Chr18:34220924-34318608 bp, + strand
Genetic Position: Chr18,
18.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:149225
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Parent Cell Line:
| IB10/E14IB10 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo cassette was inserted upstream of exon 15 and an additional loxP site was inserted downstream of exon 15. Cre mediated recombination removed the neo cassette leaving exon 15 floxed. (J:149225)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Apc Mutation:
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50 strains or lines available |
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| References |
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Original: |
J:149225
Miclea RL et al.,
"Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors."
BMC Dev Biol 2009;9():26
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All: |
7 reference(s)
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Analysis Tools
