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| Nomenclature |
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Symbol:
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Jag1tm1.1Loo
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Name:
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jagged 1;
targeted mutation 1.1, Kathleen M Loomes
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MGI ID: |
MGI:3848155 |
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Synonyms: |
Jag1loxP |
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Gene:
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Jag1
Location:
Chr2:137081456-137116644 bp, - strand
Genetic Position: Chr2,
67.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:149131
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neomycin cassette was placed upstream of exon 4 with an additional loxP site placed downstream of exon 5. The neomycin cassette was removed by transient expression of cre recombinase leaving exons 4 and 5 floxed. Exon 4 encodes the DSL region, which is conserved across species and is known to be crucial for ligand-receptor interactions. Deletion of exon 4 and exon 5 by cre recombinase was predicted to result in a frameshift mutation and premature truncation of the protein after 192 amino acids.(J:149131)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Jag1 Mutation:
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7 strains or lines available |
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| References |
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Original: |
J:149131
Loomes KM et al.,
"Bile duct proliferation in liver-specific Jag1 conditional knockout mice: effects of gene dosage."
Hepatology 2007 Feb;45(2):323-30
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All: |
4 reference(s)
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Analysis Tools
