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| Nomenclature |
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Symbol:
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Glis3tm1Amj
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Name:
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GLIS family zinc finger 3;
targeted mutation 1, Anton M Jetten
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MGI ID: |
MGI:3848053 |
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Synonyms: |
Glis3deltaZF5, Glis3zf |
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Gene:
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Glis3
Location:
Chr19:28258851-28680077 bp, - strand
Genetic Position: Chr19,
22.88 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:148994
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 4, which contains the sequence coding for zinc finger 5, and parts of intron 3 and 4 were replaced with a neo cassette. Deletion of zinc finger 5 (ZF5) is predicted to disrupt DNA binding ablity and transcriptional activity of the gene. The inability of the protein produced from this allele to activate transcription of a luciferase reporter with a Glis-binding site was confirmed by cellular assay. (J:148994)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Glis3 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:148994
Kang HS et al.,
"Glis3 is associated with primary cilia and Wwtr1/TAZ and implicated in polycystic kidney disease."
Mol Cell Biol 2009 May;29(10):2556-69
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All: |
2 reference(s)
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Analysis Tools
