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| Nomenclature |
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Symbol:
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Tg(CD2-Stat6*V625A*T626A)78Mhk
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Name:
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transgene insertion 78, Mark H Kaplan
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MGI ID: |
MGI:3845883 |
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Synonyms: |
Stat6VT, StatVT |
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Transgene:
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Tg(CD2-Stat6*V625A*T626A)78Mhk
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses the human STAT6 gene, with codons V625 and T626 mutated to express alanine and a C-terminal FLAG tag added, under transcriptional control of the CD2 locus control region. This promoter restricted expression of the transgene primarily to B and T lymphocytes. In addition to line 78, founder line 24 was also established. (J:133480)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:133480
Bruns HA et al.,
"Expression of a constitutively active Stat6 in vivo alters lymphocyte homeostasis with distinct effects in T and B cells."
J Immunol 2003 Apr 1;170(7):3478-87
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All: |
6 reference(s)
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Analysis Tools
