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| Nomenclature |
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Symbol:
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Tg(Slc6a3-PARK2*Q311X)AXwy
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Name:
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transgene insertion A, X William Yang
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MGI ID: |
MGI:3845880 |
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Synonyms: |
Parkin-Q311X(A), Parkin-Q311X line A, TgA |
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Transgene:
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Tg(Slc6a3-PARK2*Q311X)AXwy
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: A 200 kb mouse bacterial artificial chromosome (BAC) RP23-408F13 contains the entire 50 kb Slc6a3 gene (solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; also called dopamine transporter (DAT)) and other genes in the approximately 100 kb of 5' and 40 kbp of 3' flanking sequences. This BAC was modified by inserting a parkin-Q311X cDNA sequence (FLAG-tagged mutant human parkin gene (PARK2; Parkinson disease (autosomal recessive, juvenile) 2, parkin) carrying the Q311X truncation associated with Turkish early-onset Parkinson's disease and followed by a polyA signal) into Slc6a3 exon 2 upstream of the translation initiation codon. This modified Slc6a3-parkin(Q311X) BAC was microinjected into fertilized FVB/NJ zygotes. Line A (found to harbor two tandem integrates of the transgene) was subsequently established. (J:146833)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:146833
Lu XH et al.,
"Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein."
J Neurosci 2009 Feb 18;29(7):1962-76
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All: |
1 reference(s)
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Analysis Tools
