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| Nomenclature |
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Symbol:
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RhoTvrm1
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Name:
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rhodopsin;
translational research vision model 1
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MGI ID: |
MGI:3845396 |
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Gene:
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Rho
Location:
Chr6:115931927-115938829 bp, + strand
Genetic Position: Chr6,
53.72 cM
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Photoreceptor degeneration in RhoTvrm4/Rho+ and RhoTvrm1/Rho+ mutants is rapidly induced by exposure to bright light
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Chemically induced (ENU) |
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Mutation: | |
Single point mutation |
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Mutation details: A missense mutation changes amino acid 102, tyrosine (TAC), to histidine (CAC) .Tyr-102 is in the first extracellular loop of Rho and is also conserved among species, including human, primate, cat, dog, and rat. (J:159523)
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Inheritance: | |
Dominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Rho Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:159523
Budzynski E et al.,
"Mutations of the opsin gene (Y102H and I307N) lead to light-induced degeneration of photoreceptors and constitutive activation of phototransduction in mice."
J Biol Chem 2010 May 7;285(19):14521-33
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All: |
2 reference(s)
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Analysis Tools
