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| Nomenclature |
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Symbol:
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Tg(ACTB-TNFRSF6B)754Jwu
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Name:
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transgene insertion 754 Jiangping Wu
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MGI ID: |
MGI:3843671 |
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Synonyms: |
DcR3 Tg |
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Transgene:
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Tg(ACTB-TNFRSF6B)754Jwu
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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C3H x C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The construct consists of human full length Dcr3 (TNFRSF6B) cDNA flanked by human beta actin promoter and beta actin poly(A) signal. The construct was injected into fertilized eggs from C3H x C57BL/6 mice. Line 754 was established and analyzed further. (J:148162)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Line 17139 exhibits a phenotype similar to Line 754, including lymphadenopathy, pathologies in skin, kidney and liver and a shortened lifespan in females.
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| References |
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Original: |
J:148162
Han B et al.,
"Overexpression of human decoy receptor 3 in mice results in a systemic lupus erythematosus-like syndrome."
Arthritis Rheum 2007 Nov;56(11):3748-58
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All: |
3 reference(s)
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Analysis Tools
