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| Nomenclature |
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Symbol:
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Ep300tm2Reck
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Name:
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E1A binding protein p300;
targeted mutation 2, Richard Eckner
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MGI ID: |
MGI:3843052 |
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Synonyms: |
p300AS-neo |
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Gene:
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Ep300
Location:
Chr15:81586214-81652077 bp, + strand
Genetic Position: Chr15,
38.16 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:85950
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutations: | |
Insertion, Nucleotide substitutions |
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Mutation details: Acetyltransferase (AT) activity was ablated via the incorporation of engineered point mutations at the endogenous locus. The mutations substitute alanine and serine for tryptophan and tyrosine (WY(1466-1477)AS). This allele was used to generate Ep300tm1Reck. (J:85950)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ep300 Mutation:
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18 strains or lines available |
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| References |
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Original: |
J:85950
Roth JF et al.,
"Differential role of p300 and CBP acetyltransferase during myogenesis: p300 acts upstream of MyoD and Myf5."
EMBO J 2003 Oct 1;22(19):5186-96
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All: |
2 reference(s)
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Analysis Tools
