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| Nomenclature |
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Symbol:
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Tnfrsf4tm2(cre)Nik
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Name:
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tumor necrosis factor receptor superfamily, member 4;
targeted mutation 2, Nigel Killeen
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MGI ID: |
MGI:3843034 |
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Synonyms: |
Ox40-Cre |
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Gene:
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Tnfrsf4
Location:
Chr4:156013843-156016612 bp, + strand
Genetic Position: Chr4,
87.68 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:147746
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Parent Cell Line:
| JM-1 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: 1.7 kb of the locus containing exons 1, 2 and part of 3 was fused to an IRES-cre construct followed by a FRT-flanked neomycin selection element. After targeted recombination, the neomycin element was removed by crossing founder mice with FLPe transgenic mice. Insertion of the cre expression construct disrupted the endogenous locus, creating a null allele. Cre expression was detected in male but not female germline cells, in memory and regulatory CD4+ T cells, and in some CD8+ and naive CD4+ T cells. (J:147746)
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Recombinase activity
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Driver:
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Tnfrsf4
Summary of all recombinase alleles
driven by Tnfrsf4.
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MGI has not yet included tissue activity data for this allele in any anatomical systems.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:147746
Klinger M et al.,
"Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands."
J Immunol 2009 Apr 15;182(8):4581-9
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All: |
11 reference(s)
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Analysis Tools
