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| Nomenclature |
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Symbol:
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Tg(Ckm-IGF1R*K1003R)1Dlr
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Name:
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transgene marker 1, Derek LeRoith
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MGI ID: |
MGI:3842765 |
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Synonyms: |
MCK-KR-hIGF-IR, MKR |
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Transgene:
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Tg(Ckm-IGF1R*K1003R)1Dlr
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The promoter, enhancer 1, exon 1, first intron/enchancer 2, and first 16 base pairs of exon 2 were used to drive muscle-specific expression of a dominant-negative human gene with nucleotide substitutions that result in the amino acid substitution of arginine for lysine at position 1003 (K1003R). Five lines were created with around 12 copies of the transgene. No line names were given. (J:71205)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:71205
Fernandez AM et al.,
"Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes."
Genes Dev 2001 Aug 1;15(15):1926-34
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All: |
17 reference(s)
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Analysis Tools
