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| Nomenclature |
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Symbol:
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Gnmttm1Ymac
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Name:
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glycine N-methyltransferase;
targeted mutation 1, Yi-Meng Arthur Chen
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MGI ID: |
MGI:3842652 |
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Gene:
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Gnmt
Location:
Chr17:46725664-46729168 bp, - strand
Genetic Position: Chr17,
22.9 cM, cytoband C
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:147857
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 1 through 4 and part of exon 5 were replaced with a neo cassette. The absence of protein was confirmed by western blot analysis on hepatic lysate. (J:147857)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gnmt Mutation:
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1 strain or line available |
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| References |
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Original: |
J:147857
Liu SP et al.,
"Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver."
Hepatology 2007 Nov;46(5):1413-25
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All: |
4 reference(s)
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Analysis Tools
