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| Nomenclature |
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Symbol:
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Tg(Myh6-PRKAG2*N488I)4623Jse
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Name:
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transgene insertion 4623, Jonathan G Seidman
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MGI ID: |
MGI:3841167 |
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Synonyms: |
TGN488I |
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Transgene:
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Tg(Myh6-PRKAG2*N488I)4623Jse
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter was used to drive cardiac-specific expression of the human gene with an T to A substitution at position 1553 that results in the amino acid substitution of asparagine with isoleucine at position 488 (N488I). Eight lines were created with line 4623 selected as the representative line. This line carried 20 copies of the transgene. (J:128648)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:128648
Arad M et al.,
"Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage cardiomyopathy."
Circulation 2003 Jun 10;107(22):2850-6
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All: |
1 reference(s)
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Analysis Tools
