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| Nomenclature |
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Symbol:
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Gt(ROSA)26Sortm2(SNCA*119)Djmo
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Name:
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gene trap ROSA 26, Philippe Soriano;
Targeted mutation 2, Darren Moore
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MGI ID: |
MGI:3840596 |
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Synonyms: |
ROSA26-a-synuclein C-terminal truncation variant (Syn119), ROSA26-Syn119, ROSA26-SynCT119Tg |
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Gene:
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Gt(ROSA)26Sor
Location:
Chr6:113067428-113077333 bp, - strand
Genetic Position: Chr6,
52.73 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:147331
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: A targeting vector was designed with an SV40 splice acceptor, a loxP-flanked STOP cassette (PGK-neo and triple SV40 transcriptional termination sequence), a cDNA encoding the 119 amino acid C-terminal truncation of human alpha-synuclein associated with familial Parkinson's disease (Syn119 or SynCT119; encoding amino acids 1-119 of the full length protein), and a bovine polyadenylation signal. (J:147331, J:150777)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Authors state that 129/SvJ-derived embryonic stem cells were used.
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| References |
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Original: |
J:147331
Moore D,
"Generation of a conditional knockin allele expresing a truncated human alpha-synuclein (SNCA)"
MGI Direct Data Submission 2009;():
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All: |
2 reference(s)
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Analysis Tools
