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| Nomenclature |
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Symbol:
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Kmt2atm1.1Erns
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Name:
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lysine (K)-specific methyltransferase 2A;
targeted mutation 1.1, Patricia Ernst
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MGI ID: |
MGI:3839794 |
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Synonyms: |
Mll1F |
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Gene:
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Kmt2a
Location:
Chr9:44803355-44881296 bp, - strand
Genetic Position: Chr9,
24.84 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:147265
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Parent Cell Line:
| D3 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was inserted upstream of exon 3, and a floxed hygro cassette was inserted downstream of exon 3. Transient cre expression in ES cells was used to remove the hygro cassette. ES cells originally used to create this allele contained Mll1tm1Sjk. (J:147266)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kmt2a Mutation:
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12 strains or lines available |
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| References |
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Original: |
J:147265
Jude CD et al.,
"Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors."
Cell Stem Cell 2007 Sep 13;1(3):324-37
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All: |
5 reference(s)
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Analysis Tools
