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| Nomenclature |
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Symbol:
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Tg(Gfap-cre)77.6Mvs
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Name:
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transgene insertion 77.6, Michael V Sofroniew
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MGI ID: |
MGI:3838840 |
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Synonyms: |
mGFAP-Cre |
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Transgene:
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Tg(Gfap-cre)77.6Mvs
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(BALB/c x C57BL/6NHsd)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The bacterial Cre recombinase gene was inserted into the first exon of an expression cassette (clone 445) that contains all the introns, promoter regulatory elements, exons, and 2.5 kb of 5' and 2 kb of 3' flanking DNA of the astroglia-specific mouse glial fibrillary acidic protein gene. GFAP is not expressed from the transgene due to deletion of part of exon 1. Cre expression was detected in a small population of cells within the subependymal zone in the adult brain. No Cre expression or activity was detected during embryonic development or in the hippocampus. (J:94543, J:146630)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:146630
Gregorian C et al.,
"Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis."
J Neurosci 2009 Feb 11;29(6):1874-86
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All: |
4 reference(s)
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Analysis Tools
