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| Nomenclature |
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Symbol:
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Prom1tm1Pec
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Name:
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prominin 1;
targeted mutation 1, Peter Carmeliet
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MGI ID: |
MGI:3838534 |
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Gene:
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Prom1
Location:
Chr5:43993622-44101736 bp, - strand
Genetic Position: Chr5,
23.97 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:146585
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 0.6 kb fragment encompassing exon 2 was replaced with a floxed neo cassette via homologous recombination. In situ hybridization analysis confirmed the absence of mRNA expression in retinas from homozygous mice. (J:146585)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Prom1 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:146585
Zacchigna S et al.,
"Loss of the cholesterol-binding protein prominin-1/CD133 causes disk dysmorphogenesis and photoreceptor degeneration."
J Neurosci 2009 Feb 18;29(7):2297-308
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All: |
4 reference(s)
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Analysis Tools
