Tg(Wfs1-cre/ERT2)3Aibs
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Wfs1-cre/ERT2)3Aibs
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Name:
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transgene insertion 3, Ed Lein
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MGI ID: |
MGI:3838496 |
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Synonyms: |
Wfs1-Tg3-CreERT2 |
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Transgene:
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Tg(Wfs1-cre/ERT2)3Aibs
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x C3H)F1 x C57BL/6
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The 196 kb C57BL/6J mouse bacterial artificial chromosome (BAC) RP23-405O19, containing the entire Wsf1 locus (and other genes), was modified by targeting a CreERT2 fusion gene (Cre-ERT2; Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain), SV40 polyA signal, and frt-flanked neomycin cassette to the ATG start site of the Wsf1 locus. The targeted BAC sequences were further modified using FLP recombination to remove the selection cassette and linearized to remove its original vector backbone. Cre activity is directed to cortex, hippocampus, striatum, thalamus and cerebellum only following taxomifen administration. (J:146821, J:155793)
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Recombinase activity
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Activity in:
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adipose tissue,
alimentary system,
cardiovascular system,
endocrine system,
hemolymphoid system,
integumental system,
liver & biliary system,
muscle,
nervous system,
renal & urinary system,
reproductive system,
respiratory system,
sensory organs
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Driver:
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Wfs1
Summary of all recombinase alleles
driven by Wfs1.
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:155793
Madisen L et al.,
"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain."
Nat Neurosci 2010 Jan;13(1):133-40
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All: |
3 reference(s)
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Analysis Tools
