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| Nomenclature |
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Symbol:
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Usp1tm1.1Ada
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Name:
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ubiquitin specific peptidase 1;
targeted mutation 1.1, Alan D D'Andrea
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MGI ID: |
MGI:3838373 |
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Gene:
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Usp1
Location:
Chr4:98923810-98935543 bp, + strand
Genetic Position: Chr4,
45.6 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:146616
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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C57BL/6
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: Exon 3 was flanked by loxP sites with a FRT-flanked neomycin resistance cassette placed downstream. Before microinjection into blastocystes, the neomycin cassette was excised by transient expression of Flp-recombinase. Mice were crossed with EIIa-cre transgenic mice to remove the floxed allele. No protein was detected by immunoblot analysis of homozygote embryonic fibroblast lysates. (J:146616)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Usp1 Mutation:
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10 strains or lines available |
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Notes |
Phenotypic Similarity to Human Syndrome: Fanconi Anemia in homozygous mice (J:146616)
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| References |
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Original: |
J:146616
Kim JM et al.,
"Inactivation of murine Usp1 results in genomic instability and a Fanconi anemia phenotype."
Dev Cell 2009 Feb;16(2):314-20
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All: |
2 reference(s)
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Analysis Tools
