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| Nomenclature |
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Symbol:
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Agpat2tm1Garg
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Name:
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1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta);
targeted mutation 1, Abhimanyu Garg
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MGI ID: |
MGI:3838346 |
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Gene:
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Agpat2
Location:
Chr2:26593057-26604417 bp, - strand
Genetic Position: Chr2,
18.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:146649
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Genomic sequence spanning from upstream of exon 1 through exon 4 was replaced with a neo cassette. RT-PCR confirmed the absence of transcript expression. Enzymatic activity of the targeted protein is reduced to 10% of wild-type. (J:146649)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Agpat2 Mutation:
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4 strains or lines available |
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| References |
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Original: |
J:146649
Cortes VA et al.,
"Molecular mechanisms of hepatic steatosis and insulin resistance in the AGPAT2-deficient mouse model of congenital generalized lipodystrophy."
Cell Metab 2009 Feb;9(2):165-76
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All: |
2 reference(s)
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Analysis Tools
