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| Nomenclature |
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Symbol:
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Tg(Myh6-MYL2*D166V)1Dsc
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Name:
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transgene insertion 1, Danuta Szczesna-Cordary
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MGI ID: |
MGI:3838172 |
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Synonyms: |
Tg-D166V |
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Transgene:
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Tg(Myh6-MYL2*D166V)1Dsc
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse cardiac alpha myosin heavy chain promoter along with the first two exons and part of the third was used to drive cardiac-specific expression of a mutated human cDNA derived from patient with familial hypertrophic cardiomyopathy that contains an amino acid substitution of valine for aspartic acid at position 166 (D166V). No line information was given. (J:146091)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:146091
Kerrick WG et al.,
"Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice."
FASEB J 2009 Mar;23(3):855-65
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All: |
1 reference(s)
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Analysis Tools
