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| Nomenclature |
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Symbol:
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Tg(Myh7-RARA/lacZ)30Mcco
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Name:
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transgene insertion 30, Melissa C Colbert
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MGI ID: |
MGI:3838149 |
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Synonyms: |
beta-MyHC-hRARalpha-CB |
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Transgene:
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Tg(Myh7-RARA/lacZ)30Mcco
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The mouse promoter was used to drive cardiac-specific expression of a human cDNA truncated at amino acid 448 and fused in frame via a collagen linker to lacZ. This truncation and fusion produces a constitutively active form. Two lines (30 and 32) were created. Line 30 has 12 copies of the transgene. (J:146424)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:146424
Colbert MC et al.,
"Cardiac compartment-specific overexpression of a modified retinoic acid receptor produces dilated cardiomyopathy and congestive heart failure in transgenic mice."
J Clin Invest 1997 Oct 15;100(8):1958-68
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All: |
1 reference(s)
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Analysis Tools
