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| Nomenclature |
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Symbol:
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Col1a1tm1(CAG-EGFR)Char
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Name:
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collagen, type I, alpha 1;
targeted mutation 1, Al Charest
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MGI ID: |
MGI:3837824 |
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Synonyms: |
Col1alpha1-EGFRWT |
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Gene:
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Col1a1
Location:
Chr11:94936224-94953042 bp, + strand
Genetic Position: Chr11,
59.01 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:146494
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Parent Cell Line:
| v6.5 (ES Cell) |
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Strain of Origin:
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(C57BL/6 x 129S4/SvJae)F1
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A CAG promoter was used to drive expression of a wild-type human EGFR with an intervening floxed STOP cassette inserted into the 3' untranslated region. (J:146494)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Col1a1 Mutation:
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64 strains or lines available |
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| References |
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Original: |
J:146494
Zhu H et al.,
"Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis."
Proc Natl Acad Sci U S A 2009 Feb 24;106(8):2712-6
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All: |
3 reference(s)
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Analysis Tools
