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| Nomenclature |
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Symbol:
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Ccm2tm1.1Etl
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Name:
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cerebral cavernous malformation 2;
targeted mutation 1.1, Elisabeth Tournier-Lasserve
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MGI ID: |
MGI:3837686 |
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Synonyms: |
Ccm2- |
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Gene:
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Ccm2
Location:
Chr11:6546887-6596744 bp, + strand
Genetic Position: Chr11,
4.45 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:146210
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: A floxed GFP/hygromycin resistance cassette was placed upstream of exon 3 and an additional loxP site was placed downstream of exon 4. Chimeric mice were bred with Tg(rtetR-TetO-cre)40Mhz mice to remove the selection cassette and exons 3 and 4. Gene inactivation was confirmed by a lack of protein detected in immunoblot analysis of E9.5 embryo lysates. (J:146210)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ccm2 Mutation:
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31 strains or lines available |
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| References |
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Original: |
J:146210
Boulday G et al.,
"Tissue-specific conditional CCM2 knockout mice establish the essential role of endothelial CCM2 in angiogenesis: implications for human cerebral cavernous malformations."
Dis Model Mech 2009 Mar;2(3-4):168-77
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All: |
2 reference(s)
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Analysis Tools
