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| Nomenclature |
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Symbol:
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Eef1a1tm1(Kras*)Arge
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Name:
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eukaryotic translation elongation factor 1 alpha 1;
targeted mutation 1, Argiris Efstratiadis
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MGI ID: |
MGI:3837679 |
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Synonyms: |
Eef1a1-Kras* |
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Gene:
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Eef1a1
Location:
Chr9:78478449-78489151 bp, - strand
Genetic Position: Chr9,
43.65 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:146290
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo STOP cassette was inserted along with a constitutively active Kras with the amino acid substitution of aspartic acid for glycine at position 12 (G12D) into intron 1. Cre mediated removal of the STOP cassette is required to achieve expression of the constitutively active Kras. (J:146290)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Eef1a1 Mutation:
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48 strains or lines available |
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| References |
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Original: |
J:146290
Klinakis A et al.,
"Igf1r as a therapeutic target in a mouse model of basal-like breast cancer."
Proc Natl Acad Sci U S A 2009 Feb 17;106(7):2359-64
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All: |
1 reference(s)
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Analysis Tools
