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| Nomenclature |
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Symbol:
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Tg(ACTB-Peo1*)DSuom
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Name:
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transgene insertion D, Anu Suomalainen
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MGI ID: |
MGI:3836897 |
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Synonyms: |
Twinkledup |
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Transgene:
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Tg(ACTB-Peo1*)DSuom
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The human promoter was used to drive ubiquitous expression of the mouse gene with a silent point mutation at position 1077 (c.1077C->G) that forms a restriction enzyme site and allows for the insertion of 39 nucleotides. This produces a duplication of amino acids 353 to 365. Four lines were produced (C, D, E, and F) with line D selected as the representative line. (J:104378)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:104378
Tyynismaa H et al.,
"Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice."
Proc Natl Acad Sci U S A 2005 Dec 6;102(49):17687-92
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All: |
2 reference(s)
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Analysis Tools
