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| Nomenclature |
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Symbol:
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Thrbtm1Mkni
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Name:
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thyroid hormone receptor beta;
targeted mutation 1, Marlies Knipper
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MGI ID: |
MGI:3836780 |
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Synonyms: |
TRbeta L2, TRbetalox |
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Gene:
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Thrb
Location:
Chr14:17660960-18038086 bp, + strand
Genetic Position: Chr14,
7.08 cM, cytoband A3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:145941
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: LoxP sites were introduced 5' and 3' of exon 5 and an frt-flanked neo cassette was introduced downstream of the 3' loxP site via homologous recombination. The neo cassette was then removed by FLP mediated recombination leaving behind a single frt site. (J:145941)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Thrb Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:145941
Winter H et al.,
"Deafness in TRbeta mutants is caused by malformation of the tectorial membrane."
J Neurosci 2009 Feb 25;29(8):2581-7
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All: |
2 reference(s)
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Analysis Tools
