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| Nomenclature |
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Symbol:
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Cdc25atm1Hpw
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Name:
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cell division cycle 25A;
targeted mutation 1, Helen Piwnica-Worms
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MGI ID: |
MGI:3836585 |
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Synonyms: |
Af, Cdc25Af |
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Gene:
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Cdc25a
Location:
Chr9:109875579-109893888 bp, + strand
Genetic Position: Chr9,
59.81 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:145768
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was introduce 5' of exon 1 and a loxP-flanked selection cassette was introduced to intron 3 via 129X1/SvJ-derived RW4 embryonic stem (ES) cells. ES cell clones containing the recombinant allele were expanded and transiently transfected with a plasmid encoding Cre recombinase under the control of the CMV promoter to remove the selection cassette, but leave floxed exons 1-3. (J:145768)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:145768
Lee G et al.,
"Response of small intestinal epithelial cells to acute disruption of cell division through CDC25 deletion."
Proc Natl Acad Sci U S A 2009 Mar 9;():
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All: |
3 reference(s)
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Analysis Tools
