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| Nomenclature |
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Symbol:
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Cacna1atm3Maag
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Name:
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calcium channel, voltage-dependent, P/Q type, alpha 1A subunit;
targeted mutation , Arn van den Maagdenberg
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MGI ID: |
MGI:3836195 |
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Synonyms: |
Cacna1aS218L, Cacna1atm1Caya, FHM-1 |
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Gene:
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Cacna1a
Location:
Chr8:84388440-84640246 bp, + strand
Genetic Position: Chr8,
40.95 cM
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Neurological deficits after spreading depression in Cacna1atm1Maag/Cacna1atm1Maag and Cacna1atm3Maag/Cacna1atm3Maag mice
Show the 1 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:144701
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A transition of C to T results in the amino acid substitution of leucine for serine at position 218 (S218L). A floxed neo cassette inserted upstream of exon 5 was removed by germ line, cre mediated recombination. (J:144701)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cacna1a Mutation:
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43 strains or lines available |
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| References |
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Original: |
J:144701
Eikermann-Haerter K et al.,
"Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1."
J Clin Invest 2009 Jan;119(1):99-109
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All: |
4 reference(s)
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Analysis Tools
