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| Nomenclature |
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Symbol:
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Tg(MMTV-AURKA)#Cxd
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Name:
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transgene insertion, Chu-Xia Deng
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MGI ID: |
MGI:3836060 |
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Synonyms: |
MMTV-Aurora-A |
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Transgene:
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Tg(MMTV-AURKA)#Cxd
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The coding sequence for the human AURKA gene (Aurora-A) was placed under the control of the mouse mammary tumor virus enhancer and promoter. Six founder lines were established using the transgene construct with the two highest expressing lines pooled for phenotypic analysis. Transgene expression for both lines was highestin the mammary and salivary glands, followed by (in descending order of expression) kidney, spleen, liver, brain, and uterus. (J:145680)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:145680
Wang X et al.,
"Overexpression of aurora kinase A in mouse mammary epithelium induces genetic instability preceding mammary tumor formation."
Oncogene 2006 Nov 16;25(54):7148-58
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All: |
1 reference(s)
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Analysis Tools
